Oddsmakers currently have the Trojans listed as 32-point favorites versus the Fighting Irish, while the game's total is sitting at 48.
Jimmy Clausen threw for 289 yards and two touchdowns for Notre Dame as they were upset 24-23 by Syracuse in Week 13.
The Irish failed to cover the 19.5-point spread, while the final score played just UNDER the posted total of 48.
USC scored 28 points in the second half to earn a 45-23 victory over Stanford in Week 12. USC failed to cover the 24-point spread, while the 68 points sailed OVER the posted total of 48.
Stafon Johnson carried the ball 14 times for 116 yards and two touchdowns.
A few trends to consider:
The total has gone UNDER in 10 of Notre Dame's last 11 games on the road
Notre Dame is 6-2 ATS in its last 8 games on the road
Notre Dame is 4-8 SU in its last 12 games on the road
Notre Dame is 2-4 SU in its last 6 games
Southern Cal is 5-0 SU in its last 5 games
Southern Cal is 5-0 SU in its last 5 games at home
Southern Cal is 5-0 SU in its last 5 games when playing Notre Dame
Southern Cal is 5-1 ATS in its last 6 games at home
Next up:
Southern Cal at UCLA, Saturday, December 6