Oddsmakers currently have the Giants listed as 10½-point favorites versus the 49ers, while the game's total is sitting at 46½.
The 49ers lost to Philadelphia 40-26 as a 5-point underdog in Week 6. The combined score went OVER the posted over/under total (41.5).
J.T. O'Sullivan threw for 212 yards with no touchdowns and two interceptions for San Francisco, while Frank Gore rushed for 99 yards and a touchdown on 19 carries.
Eli Manning was 18-for-28 for 196 yards with a touchdown and three interceptions for New York in its 35-14 loss to Cleveland in Week 6 action on Monday night.
Cleveland cashed as 7-point home underdogs as the game played over the 43-point total set by oddsmakers.
New York most recently:
When playing in October are 9-1
When playing on turf are 7-3
After being outgained are 6-4
When playing outside the division are 8-2
San Francisco most recently:
When playing in October are 2-8
When playing on turf are 4-6
After being outgained are 0-10
When playing outside the division are
San Francisco has lost 3 straight games.
Team records:
San Francisco: 2-4 SU, 2-4 ATS
New York: 4-1 SU, 3-2 ATS