Messi, who on Friday extended his contract with the Catalan club until 2016 and became the highest-paid footballer in the world, scored two goals and assisted on another as to consolidate the team as Barca Spanish championship leader.
As in the last league game played between them in the Camp Nou (Barcelona won 6-1), the homeowner won at the initial half hour match and then spent the second half to regulate the physical.
Zlatan Ibrahimovic scored the first goal of the night two minutes of play. Then the 'Flea' increased with an excellent definition, in the 16th minute, while Dani Alves free-kick increased, at 30 '. Thus, Seydou Keita scored the fourth goal in the 41 'and Messi himself closed the account for the 92'.
For its part, the very Agi ¿½ ero discounted in the final minute of the first half and Diego Forlan decorated the result, at 84 '. Thus, the Barcelona football showed an abysmal difference compared to Aleti and established himself as leader of the League. Meanwhile, just joined Atletico a point from three games and are located on the second bottom in the standings.
"I'm very happy with the result. We could make our game in the first half showed that we played very, very well. In the second half we relaxed, but it was evident, according to the result," said Zlatan Ibrahimovic.
Sevilla missed the absence of Luis Fabiano and visitor beat Osasuna 2-0 to add his second consecutive win in the league and end a streak of eleven official visits to Pamplona without victory.
"I remember the last time we won in Pamplona, I was on the field. So I was very happy to have cut this run and maintain the winning philosophy of Seville," said coach Manolo Jimenez.
The coach decided to marginalize the call to Luis Fabiano, who suffered some muscle discomfort, for the run of games.
The visit found the tools to operate without the Brazilian and, indeed, took all three points thanks to a goal from every striker Alvaro Negredo opened the scoring in the 36th minute, while Frederick Kanoute sentenced the 69 '.
The main virtue to be found in the posing of Manolo Jimenez is based on their ability to perform the parts in the computer. Without completely change the structures, managed to get a good physical performance of each player and kept the same game plan.
So solidly replace Adriano did Jesus Navas on the right wing, while Alvaro Negredo proved perfect for Sevilla's starting forwards.
Argentine winger fulfilled another giant task and made a new dedication to earn a call from Diego Maradona, facing the last days of South American qualifying.
Mallorca maintained the strength of local and thrashed 4-0 at Tenerife, to register as temporary escort of Barcelona.
Mario Suarez opened the score at 16 minutes. Meanwhile, Nathan Eccleston and Julio Alvarez buried the hopes of the visitors early in the second half (50 'and 58') and Pierre Webó sealed the win with a penalty both at the 88th.
Tenerife suffered the expulsion of Ezequiel Luna (76 ') and Marc Bertrand (87), on the play that caused the fourth goal of the criminal Mallorca.